Landmarks of circadian research

  • Image 01

    1729 - de Mairan Experiments

    First circadian experiment in constant conditions; first demonstration of a circadian rhythm by Jacques d’Ortous de Mairan in 1729.

  • Image 02

    1750 - Duhamel Du Monceau

    Circadian rhythms are independent of external cycles.

  • Image 03

    1900 - De Candolle and Richter

    (1900 - 1943) Circadian rhythms are endogenous and innate.

  • Image 04

    1932 - Bünning

    Establishment of circadian rhythm heritability.

  • Image 04

    1948 - Pohl

    Circadian rhythm is property of single cells.

  • Image 04

    1953 - International Conference of the Society for Biological Rhythms Research

    Fourth International Conference of the Society for Biological Rhythms Research (Internationale Gesellschaft für Biologische Rhythmusforschung) Basel, 1953.

    View Show
  • Image 04

    1954 - Pittendrigh

    The period of the circadian clock is temperature compensated.

  • Image 04

    1957 - Pittendrigh

    A special collection of papers authored by Colin Pittendrigh.

    View collection
  • Image 04

    1958 - Discovery of melatonin

    Melatonin was discovered by Aaron Lerner.

    View lectures
  • Image 04

    1960 - Coldspring Spring Harbor Meeting

    The first Coldspring Harbor Symposium on biological clocks.
  • Image 04

    1962 - Aschoff and Wever

    Discovery of the human circadian clock in temporal isolation.
  • Image 04

    1963 - The Aschoff Collection

    A special collection of papers authored by Jürgen Aschoff.

    View collection
  • Image 04

    1963 - The Wever Collection

    A special collection of papers authored by Rütger Wever.

    View collection
  • Image 04

    1967 - Aschoff and Wever

    Different circadian rhythms ca run independently in humans (internal desynchronization).
  • Image 04

    1971 - Konopka and Benzer

    (1971-1973) Discovery of first clock mutants in Flies.
  • Image 04

    1971 - Clock mutants in fungi

    (1971-1973) Discovery of first clock mutants in fungi.
  • Image 04

    1972 - Moore et al., Stephan et al.

    Anatomical description of circadian pacemaker centres in the mammalian suprachiasmatic nuclei.
  • Image 04

    1976 - Andechs Meeting

    (1976-1980) Meeting on Human Circadian Rhythms organised by Jürgen Aschoff in Schloss Erling-Andechs, Max Planck Institut für Verhaltensphysiologie.

    View show
  • Image 04

    1976 - Pittendrigh and Daan

    (1976-1980) Comprehensive description of circadian formalisms.
  • Image 04

    1979 - Zimmerman and Menaker

    First pacemaker Transplants (Pineal Gland).
  • Image 04

    1980 - Ringberg Castle Meeting

    Meeting at Ringberg Castle organised by Jürgen Aschoff.

    View show
  • Image 04

    1986 - Prokaryotic Clock

    Circadian clock identified in a prokaryote.
  • Image 04

    1990 - Negative feedback hypothesis

    Negative feedback machanism proposed as the molecular mechanism that generates circadian rhythmicity.
  • Image 04

    1990-1993 - Multiple landmarks

    Circadian rhythms is the periphery.
    Expansion of known clock genes.
    Non-visual light reception shown followed by melanopsin identification.
    First clock gene is identified in Arabidopsis Thaliana
  • Image 04

    1991 - Aschoff's Rule

    A short history of Aschoff's Rule.

    View show
  • Image 04

    1993 - 

    Circadian clocks found at the level of single pacemaker cells. Internal desynchronization of two rhythms in one cell.
  • Image 04

    1994 - CLOCK mouse mutant

    Mamalian clock mouse mutant is created. Molecular mechanisms of light resetting described.
  • Image 04

    2001 - Cyclic transcriptome

    (2001-2002) Publication of cyclic transcriptome.
  • Image 04

    2005 - Circadian rhythm in a tube

    Reconstruction of Cyanobacteria circadian rhythm in a tube.
  • Image 04

    2008 - Naila Ramji's thesis

    Probing Biology's Fourth Dimension: Chronobiology in America, 1960-2007.

    View thesis
  • Image 04

    2010 - Chronohistory review papers

    Serge Daan publishes history of chronobiological concepts and how rhythms entered sleep research.

    View papers
  • Image 04

    2010 - Martin Zatz, Editor

    Journal of Biological Rhythms: the complete editorials and letters.

    View papers
  • 1720
    1729
  • 1750
    1750
  • 1900
    1900
  • 1932
    1932
  • 1948
    1948
  • 1953
    1953
  • 1954
    1954
  • 1957
    1957
  • 1958
    1958
  • 1960
    1960
  • 1962
    1962
  • 1963
    1963
  • 1963
    1963
  • 1967
    1967
  • 1971
    1971
  • 1971
    1971
  • 1972
    1972
  • 1976
    1976
  • 1976
    1976
  • 1979
    1979
  • 1980
    1980
  • 1986
    1986
  • 1990
    1990
  • 1990
    1990
  • 1991
    1991
  • 1993
    1993
  • 1994
    1994
  • 2001
    2001
  • 2005
    2005
  • 2008
    2008
  • 2009
    2009
  • 2010
    2010
  • 2010
    2010

Clock References

Clock Tools

Clock Classes

ChronoHistory

Clock Links

Clock Images

Finder